Corifollitropin alfa in different variants of ovarian response in assisted reproductive technology programmes: literature review

This literature review focuses on the use of corifollitropin alfa for ovarian stimulation in assisted reproductive technology (ART) programmes different groups patients. Corifollitropin is a gonadotropin drug with prolonged FSH activity. The main difference between and other gonadotropins higher level peak FSH, which leads to recruitment more follicles. Another feature inability adjust dose during first days stimulation. In contrast traditional indications/contraindications gonadotropins, cortifollitropin not recommended combination GnRH agonists or patients polycystic ovary syndrome. Evidence feasibility efficacy using various response variants ART has been analysed. Most researchers agree that can be presumed poor normal response. excessive timulation possible when embryo transfer expected: oocyte donation/oocyte vitrification cycles "freeze-all" cycles. A significant advantage donor single administration drug, done medical facility, reduces risk prescription non-compliance. protocols requires further research: firstly, no LH component secondly, there possibility ovulation trigger replacement this protocol if high early hyperstimulation